Jenna Mae Tokens, seven, is waiting for a bone marrow transplant but can't have the treatment until a suitable donor is found. None of her family are matches.
Jenna has been in Leicester Royal Infirmary since she was diagnosed with leukaemia in May.
Her Mum Tracy said: "It would mean everything to find a donor.
"Some mornings I wake up and just want to cry and other days I feel that I am more able to cope."
She is keeping vigil at Jenna's bedside and only sees her other two children, Jarred, 13 and Jordane, 14, and partner Ian Lemon once a fortnight because they don't have transport to take them to the hospital in Leicester.
Ms Tokens, of Devon Walk Way, Kettering, said: "When my oldest daughter Jordane came to visit someone told her if we couldn't find a donor Jenna would die, which devastated her. It is so tough not being able to see them."
Jenna, a pupil at Grange Primary School in Kettering, is having a third course of chemotherapy to remove white blood cells to prepare her for a bone marrow transplant which she will receive at a specialist centre in Sheffield.
She is in isolation at the hospital and staff have organised a Mamma Mia sing-a-long to keep her spirits up and provided a DVD player so that she can watch her favourite film High School Musical.
Ms Tokens said: "She is being very brave and her spirits are generally very high but she has good days and bad days."
The Anthony Nolan Trust has arranged a donor registration session to help find a suitable match.
Debby Jepps from the trust said: "Jenna is very sick and her family are going through a difficult time.
"Anyone wishing to be a bone marrow donor must be between 18 and 40 and in good health to try to get the best match for Jenna."
The donor session will take place from 4.30pm to 7.30pm on Thursday, September 25, at Brambleside Primary School, Kettering. For more information visit
www.anthonynolan.org.uk.
The full article contains 383 words and appears in Northants Evening Telegraph newspaper.